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Radiocarbon Detection / C14-SCAR for Pharma

C14-SCAR for Pharma

The natural ¹⁴C label can be artificially enriched (even by orders of magnitude) to mark drugs and track their metabolic pathways in human clinical trials.

The unprecedented C14-SCAR dynamic range can enable seamless measurements over more than 5 decades of radiocarbon concentration (0.1 – 100000 pMC).

Since only small  samples (urine, plasma, feces, etc.) are typically available, a specific, smaller volume model of the instrument,  named BIO-SCAR, has been developed for this kind of application.

Measurement process explained

C14-SCAR for Pharma is able to continuously measure previously treated biological samples, the measurement phase is divided into two steps:

1. Loading the sample set and burning

To enable fast analysis, a set of samples can be placed in a loader for automated measurement.
The sample set is sent to an elemental analyser (EA) which performs the burn. The output of the EA is a stream of a mixture of CO2 and He (carrier gas).

2. Purification and measurement

The output of the EA is trapped and purified inside C14-SCAR and transferred to the measuring cell.
When the measuring cell has been filled to the correct pressure, the Saturated CAvity Ring-down process begins and measurements are taken.
The analysis result is provided automatically after the measurement.

Performances

14C-SCAR for Pharma  achieves excellent sensitivity at low measurement times, has a very wide dynamic range, about 4 decades, and requires a low amount of sample to operate.

With measurement times in the order of 120min 14C-SCAR achieves sub-pmc accuracies.

–

MIN

TYP

MAX

UNIT

CARBON SAMPLE MASS

–

1

 2

mg

PRECISION

–

–

 –

 –

   12min

1

1.5

 –

pMC

  60min

0.4

0.6

 –

pMC

240min

0.2

0.3

 –

pMC

ACCURACY

0.2

0.5

 –

%

MEASUREMENT RANGE

1

–

104

pMC

LIMIT OF DETECTION

1

–

 –

pMC

CARBON SAMPLE MASS [mg]

MIN

–

TYP

1

MAX

2

PRECISION@12min [pMC]

MIN

1

TYP

1.5

MAX

–

PRECISION@60min [pMC]

MIN

0.4

TYP

0.6

MAX

–

PRECISION@120min [pMC]

MIN

0.2

TYP

0.3

MAX

–

ACCURACY [%]

MIN

0.2

TYP

0.5

MAX

–

MEASUREMENT RANGE [pMC]

MIN

1

TYP

–

MAX

104

LIMIT OF DETECTION [pMC]

MIN

1

TYP

–

MAX

–

C14-SCAR for Pharma

The natural ¹⁴C label can be artificially enriched (even by orders of magnitude) to mark drugs and track their metabolic pathways in human clinical trials.

The unprecedented C14-SCAR dynamic range can enable seamless measurements over more than 5 decades of radiocarbon concentration (0.1 – 100000 pMC).

Since only small  samples (urine, plasma, feces, etc.) are typically available, a specific, smaller volume model of the instrument,  named BIO-SCAR, has been developed for this kind of application.

Measurement process explained

C14-SCAR for Pharma is able to continuously measure previously treated biological samples, the measurement phase is divided into two steps:

1. Loading the sample set and burning

To enable fast analysis, a set of samples can be placed in a loader for automated measurement.
The sample set is sent to an elemental analyser (EA) which performs the burn. The output of the EA is a stream of a mixture of CO2 and He (carrier gas).

2. Purification and measurement

The output of the EA is trapped and purified inside C14-SCAR and transferred to the measuring cell.
When the measuring cell has been filled to the correct pressure, the Saturated CAvity Ring-down process begins and measurements are taken.
The analysis result is provided automatically after the measurement.

Performances

14C-SCAR for Pharma  achieves excellent sensitivity at low measurement times, has a very wide dynamic range, about 4 decades, and requires a low amount of sample to operate.

With measurement times in the order of 120min 14C-SCAR achieves sub-pmc accuracies.

–

MIN

TYP

MAX

UNIT

CARBON SAMPLE MASS

–

1

 2

mg

PRECISION

–

–

 –

 –

   12min

1

1.5

 –

pMC

  60min

0.4

0.6

 –

pMC

240min

0.2

0.3

 –

pMC

ACCURACY

0.2

0.5

 –

%

MEASUREMENT RANGE

1

–

104

pMC

LIMIT OF DETECTION

1

–

 –

pMC

CARBON SAMPLE MASS [mg]

MIN

–

TYP

1

MAX

2

PRECISION@12min [pMC]

MIN

1

TYP

1.5

MAX

–

PRECISION@60min [pMC]

MIN

0.4

TYP

0.6

MAX

–

PRECISION@120min [pMC]

MIN

0.2

TYP

0.3

MAX

–

ACCURACY [%]

MIN

0.2

TYP

0.5

MAX

–

MEASUREMENT RANGE [pMC]

MIN

1

TYP

–

MAX

104

LIMIT OF DETECTION [pMC]

MIN

1

TYP

–

MAX

–