Radiocarbon Detection / C14-SCAR for Pharma
C14-SCAR for Pharma
The natural ¹⁴C label can be artificially enriched (even by orders of magnitude) to mark drugs and track their metabolic pathways in human clinical trials.
The unprecedented C14-SCAR dynamic range can enable seamless measurements over more than 5 decades of radiocarbon concentration (0.1 – 100000 pMC).
Since only small samples (urine, plasma, feces, etc.) are typically available, a specific, smaller volume model of the instrument, named BIO-SCAR, has been developed for this kind of application.
Measurement process explained
C14-SCAR for Pharma is able to continuously measure previously treated biological samples, the measurement phase is divided into two steps:
1. Loading the sample set and burning
To enable fast analysis, a set of samples can be placed in a loader for automated measurement.
The sample set is sent to an elemental analyser (EA) which performs the burn. The output of the EA is a stream of a mixture of CO2 and He (carrier gas).
2. Purification and measurement
The output of the EA is trapped and purified inside C14-SCAR and transferred to the measuring cell.
When the measuring cell has been filled to the correct pressure, the Saturated CAvity Ring-down process begins and measurements are taken.
The analysis result is provided automatically after the measurement.
Performances
14C-SCAR for Pharma achieves excellent sensitivity at low measurement times, has a very wide dynamic range, about 4 decades, and requires a low amount of sample to operate.
With measurement times in the order of 120min 14C-SCAR achieves sub-pmc accuracies.
–
MIN
TYP
MAX
UNIT
CARBON SAMPLE MASS
–
1
2
mg
PRECISION
–
–
–
–
12min
1
1.5
–
pMC
60min
0.4
0.6
–
pMC
240min
0.2
0.3
–
pMC
ACCURACY
0.2
0.5
–
%
MEASUREMENT RANGE
1
–
104
pMC
LIMIT OF DETECTION
1
–
–
pMC
CARBON SAMPLE MASS [mg]
MIN
–
TYP
1
MAX
2
PRECISION@12min [pMC]
MIN
1
TYP
1.5
MAX
–
PRECISION@60min [pMC]
MIN
0.4
TYP
0.6
MAX
–
PRECISION@120min [pMC]
MIN
0.2
TYP
0.3
MAX
–
ACCURACY [%]
MIN
0.2
TYP
0.5
MAX
–
MEASUREMENT RANGE [pMC]
MIN
1
TYP
–
MAX
104
LIMIT OF DETECTION [pMC]
MIN
1
TYP
–
MAX
–
C14-SCAR for Pharma
The natural ¹⁴C label can be artificially enriched (even by orders of magnitude) to mark drugs and track their metabolic pathways in human clinical trials.
The unprecedented C14-SCAR dynamic range can enable seamless measurements over more than 5 decades of radiocarbon concentration (0.1 – 100000 pMC).
Since only small samples (urine, plasma, feces, etc.) are typically available, a specific, smaller volume model of the instrument, named BIO-SCAR, has been developed for this kind of application.
Measurement process explained
C14-SCAR for Pharma is able to continuously measure previously treated biological samples, the measurement phase is divided into two steps:
1. Loading the sample set and burning
To enable fast analysis, a set of samples can be placed in a loader for automated measurement.
The sample set is sent to an elemental analyser (EA) which performs the burn. The output of the EA is a stream of a mixture of CO2 and He (carrier gas).
2. Purification and measurement
The output of the EA is trapped and purified inside C14-SCAR and transferred to the measuring cell.
When the measuring cell has been filled to the correct pressure, the Saturated CAvity Ring-down process begins and measurements are taken.
The analysis result is provided automatically after the measurement.
Performances
14C-SCAR for Pharma achieves excellent sensitivity at low measurement times, has a very wide dynamic range, about 4 decades, and requires a low amount of sample to operate.
With measurement times in the order of 120min 14C-SCAR achieves sub-pmc accuracies.
–
MIN
TYP
MAX
UNIT
CARBON SAMPLE MASS
–
1
2
mg
PRECISION
–
–
–
–
12min
1
1.5
–
pMC
60min
0.4
0.6
–
pMC
240min
0.2
0.3
–
pMC
ACCURACY
0.2
0.5
–
%
MEASUREMENT RANGE
1
–
104
pMC
LIMIT OF DETECTION
1
–
–
pMC
CARBON SAMPLE MASS [mg]
MIN
–
TYP
1
MAX
2
PRECISION@12min [pMC]
MIN
1
TYP
1.5
MAX
–
PRECISION@60min [pMC]
MIN
0.4
TYP
0.6
MAX
–
PRECISION@120min [pMC]
MIN
0.2
TYP
0.3
MAX
–
ACCURACY [%]
MIN
0.2
TYP
0.5
MAX
–
MEASUREMENT RANGE [pMC]
MIN
1
TYP
–
MAX
104
LIMIT OF DETECTION [pMC]
MIN
1
TYP
–
MAX
–